HETA (H&E Tissue Application) provides comprehensive tissue profiling for whole slide H&E images. It exceeds expert pathologist performance and is consistent across sites and scanners.
Validation
Validated for accuracy against an IHC-informed pathologist consensus, and for generalizability across 1,500+ images, 8 cancer types, 25+ labs and 8 scanners.
Accuracy
Matched or exceeded the performance of expert pathologists
0.74 vs 0.71
Macro F1 vs pathologist average
0.82 vs 0.78
Macro F1 on high-confidence calls
Generalizability
Consistent across primary and metastatic sites.
0.85–0.95
F1 across 8 cancer types and 5 metastatic sites
≥0.96
F1 detecting cancer cells at every site
HETA currently supports analyses for ten cancer types.
Performance has been validated on at least 90% of invasive morphological subtypes per cancer, as well as on different tissue (e.g., primary vs. metastatic) and sample types (e.g., resections, biopsies, FNAs).
Every slide passes through quality control, tissue segmentation and cell classification, including:
Quality control flags areas that should be excluded from downstream analyses
Cell detection and classification flags individual cells and classifies each into one of 10 classes
Tissue segmentation groups tissue into one of 7 classes
Spatial features that describe how tissue and cells are organized, including:
TLS detection identifies tertiary lymphoid structures and classifies their maturity
WTR detection identifies the tumor core, invasive margins and surrounding tissue
In addition to qualitative outputs, we provide over 4,500 quantitative metrics per image, including QC features and cell, tissue, and neighborhood-level details.
All life sciences customers are eligible for a free trial of HETA.
Try HETA on your images, public images, or commercial images. All data will be securely transferred, analyzed and deleted after the free trial.
For research use only. Not for use in diagnostic procedures.
